Basics – neurotransmitters- general principles and common transmitters, Cell membrane – Physiochemical properties, permeability and transport, bioelectricity, Genesis of resting membrane potential, action potential, properties of nerve-fibres. Neuromuscular junction, Muscle proteins, excitation – contraction coupling, injury and repair of nerves and muscles, work physiology.

Sensory system –Functional organization of sensory system, perception of sensory stimuli, coding, physiology of pain. Motor System – Functional organization of motor system, properties of reflexes, brain stem,stretch , tendon reflexes, basal ganglia cerebellum and vestibular neck reflexes , maintenance of equilibrium ,localizing the level of lesion in neurological diseases, Visceral and motivational system – autonomic nervous system, hypothalamus , limbic system,emotions, EEG , sleep and wakefulness, learning , memory and speech.

Neuropathology – Trauma, Inflammatory disorders- pyogenic and tuberculous meningitis,brain abscess, tuberculoma CSF and its disturbances – cerebral odema, raised intracranial pressure, Cerebrovascular disease – atherosclerosis, thrombosis, embolism, aneurysm, hypoxia, infarction and haemorrhage.

Clinical examination of nervous system, investigations. Major manifestations – headache, facial pain, raised intracranial tension, faintness, dizziness, syncope, vertigo, Disorders of sleep and movement, Sensory disturbances (numbness, tingling and sensory loss), acute confusional state, coma and brain death, Aphasia and focal cerebral disorders, disturbances of brain stem, vision and sphincter. Headaches – migraine, cluster and seizures.

Dementia, meningitis, encephalitis , cranial nerve diseases, spinal cord diseases , tumours ( primary and secondary), Peripheral neuropathies and demyelinating disorders, Multiple sclerosis , Parkinson’s disease, extrapyramidal disorders, cerebellar disorders. Motor neuron disease, diseases of muscles, neurological manifestations of systemic diseases, nutritional and metabolic diseases of the nervous system.