Subject Details
Dept     : B.Pharm
Sem      : 4
Regul    : 2014
Faculty : staff15 Mr. Sivasubramanian
phone  : NIL
E-mail  : snscphs005
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Syllabus

UNIT
1
Optical Isomerism

Optical activity, enantiomerism, diastereoisomerism, meso compounds Elements of symmetry, chiral and achiral molecules DL system of nomenclature of optical isomers, sequence rules, RS system of nomenclature of optical isomers Reactions of chiral molecules Racemic modification and resolution of racemic mixture. Asymmetric synthesis: partial and absolute

UNIT
2
Geometrical isomerism

Nomenclature of geometrical isomers (Cis Trans, EZ, Syn Anti systems) Methods of determination of configuration of geometrical isomers. Conformational isomerism in Ethane, n-Butane and Cyclohexane. Stereo isomerism in biphenyl compounds (Atropisomerism) and conditions for optical activity. Stereospecific and stereoselective reactions

UNIT
3
Heterocyclic compounds

Nomenclature and classification Synthesis, reactions and medicinal uses of following compounds/derivatives Pyrrole, Furan, and Thiophene Relative aromaticity and reactivity of Pyrrole, Furan and Thiophene

UNIT
4
Synthesis, reactions and medicinal uses of Heterocyclic compounds

Pyrazole, Imidazole, Oxazole and Thiazole. Pyridine, Quinoline, Isoquinoline, Acridine and Indole. Basicity of pyridine Synthesis and medicinal uses of Pyrimidine, Purine, azepines and their derivatives

UNIT
5
Reactions of synthetic importance

Metal hydride reduction (NaBH4 and LiAlH4), Clemmensen reduction, Birch reduction, Wolff Kishner reduction. Oppenauer-oxidation and Dakin reaction. Beckmanns rearrangement and Schmidt rearrangement. Claisen-Schmidt condensation

Reference Book:

1. Organic chemistry by I.L. Finar, Volume-I & II. 2. Organic Chemistry by Morrison and Boyd 3. Heterocyclic Chemistry by T.L. Gilchrist

Text Book:

1. A text book of organic chemistry – Arun Bahl, B.S. Bahl. 2. Heterocyclic Chemistry by Raj K. Bansal

 

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